A heart of gold (MIT)
A team of researchers at MIT and Children’s Hospital Boston has built cardiac
patches studded with tiny gold wires that could be used to create pieces of
tissue whose cells all beat in time, mimicking the dynamics of natural heart
muscle. The development could someday help people who have suffered heart
attacks.
The study, reported this week in _Nature Nanotechnology_, promises to improve
on existing cardiac patches, which have difficulty achieving the level of
conductivity necessary to ensure a smooth, continuous “beat” throughout a
large piece of tissue.
“The heart is an electrically quite sophisticated piece of machinery,” says
Daniel Kohane, a professor in the Harvard-MIT Division of Health Sciences and
Technology (HST) and senior author of the paper. “It is important that the
cells beat together, or the tissue won’t function properly.”
The unique new approach uses gold nanowires scattered among cardiac cells as
they’re grown in vitro, a technique that “markedly enhances the performance of
the cardiac patch,” Kohane says. The researchers believe the technology may
eventually result in implantable patches to replace tissue that’s been damaged
in a heart attack.
Co-first authors of the study are MIT postdoc Brian Timko and former MIT
postdoc Tal Dvir, …
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