Research finds HIV-killing compound (TexasAmEngineeringNewsChemical?format=xml)
A powerful topical preventative for HIV, the virus that causes AIDS, could
soon be in the works thanks to a newly discovered molecular compound that
research at Texas A&M University and the Scripps Research Institute shows
dissolves the virus on contact.
The ability of the synthetic compound known as “PD 404,182” to break apart the
AIDS-causing virus before it can infect cells was discovered by Zhilei Chen,
assistant professor in the university’s Artie McFerrin Department of Chemical
Engineering, and her team of researchers. Their findings appear in the
November online edition of “Antimicrobial Agents and Chemotherapy,” a journal
of the American Society for Microbiology.
“This is a virucidal small-molecule compound, meaning that it has the ability
to kill a virus; in this case that virus is HIV,” Chen says. “Basically, it
acts by breaking the virus open. We found that when HIV comes in contact with
this compound, it breaks open and loses its genetic material. In a sense, the
virus ‘dissolves,’ and its RNA becomes exposed. Since RNA is pretty unstable,
once it is exposed it’s gone very quickly and the virus is rendered non-
infectious.”
In other words, the compound works by quickly ripping open …
TexasAmEngineeringNewsChemical?format=xml
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